Turmeric—or extra specially its primary bioactive compound, curcumin—is one of the most common nutraceuticals in use currently. In reality, a report1 by Grand View Study predicted that the world-wide curcumin industry will reach $94.3 million by 2022. This is regular with a a lot more modern report from World wide Market place Insights2, whose facts predicts the international curcumin current market will exceed $145 million by 2027.
Why is curcumin so well known? Like vitamin D, curcumin is 1 of individuals nutraceuticals for which analysis implies a broad assortment of possible positive aspects. Likewise, turmeric has been used as a standard solution in Chinese and Indian Ayurvedic drugs for more than 2,000 years3, and the authors of a textbook on bioactive food items indicate that “the use of turmeric in Indian folk medication is a person of a veritable panacea, seemingly efficacious for conditions that we would at present classify in the realm of infectious, inflammatory, metabolic, and immunological diseases.”4
A person of curcumin’s lesser-identified added benefits is its results on worry/stress and sleep.
How can curcumin assist regulate worry/panic and slumber? The respond to is serotonin. Serotonin is a neurotransmitter that stabilizes our mood, feelings of well-being, and joy. This neurotransmitter also allows with sleeping, consuming, and digestion.
As it turns out, in animal exploration, curcumin supplementation was discovered to increase serotonin levels.5 In 1 examine6, chronically pressured rats were supplemented with curcumin. Curcumin considerably prevented the strain-induced lessen in serotonin, serving to to overcome pressure-induced behavioral abnormalities. In a further rat study, curcumin supplementation served restore serotonin equilibrium when alcoholic beverages use had adversely influenced it.7
Tension/Stress and anxiety
Long-term publicity to tension is a perfectly-identified possibility factor for the growth of mood and anxiousness diseases. Researchers tested8 the efficacy of curcumin in selling resilience to serious social stress in mice. The curcumin administration developed a 4.5-fold boost in stress resilience in the greater part of mice. These mice also produced a lot less corticosterone (a tension hormone) subsequent acute restraint stress, and had reduce ranges of peripheral IL-6 (an inflammatory compound). Curcumin also prevented anxiety-like conduct.
The outcomes of curcumin (1 g/working day) or placebo ended up also analyzed on the frequency of symptoms of anxiousness and melancholy in 30 overweight human subjects in a 30-working day, double-blind, crossover trial.9 Severity of nervousness and despair was assessed at baseline and at months 4, 6, and 10 of the demo utilizing the Beck Stress Stock and Beck Depression Stock, equally scientifically validated evaluation questionnaires. Outcomes showed that stress scores were considerably decreased adhering to curcumin remedy (P=.03).
Comparable final results have been noticed in other exploration, like reports on:
- 80 mg of nano-curcumin displaying success in reducing depression and stress and anxiety scores in patients with diabetic polyneuropathy10
- 500-1000 mg of curcumin and mixed curcumin/saffron demonstrating success in reducing despair and stress signs in people with main depressive problem11
- 1 g of curcumin exhibiting anti-anxiousness result in folks with obesity12
- 1000 mg of curcumin in addition 10 mg of piperine demonstrating substantially larger lessened anxiety and depression signs as an add-on to regular medication in sufferers with big depressive disorder13
A randomized, double-blind, placebo-managed trial14 was performed to confirm the outcomes of 1000 mg/working day curcumin or placebo on excellent of existence (QoL) in 58 patients aged 20-70 yrs with liver cirrhosis. When compared with baseline, general QoL scores enhanced noticeably (P < 0.05) after curcumin administration. Furthermore, curcumin helped significantly reduce (P < 0.05) the following: sleeping during the day, decreased sexual interest, and decreased sexual activity.
Another study15 was conducted to examine the effect of turmeric supplementation on quality of life (QoL) and hematological parameters in 60 breast cancer patients on chemotherapy. Turmeric supplementation for 21 days resulted in clinically relevant and statistically significant improvement in global health status symptom scores, including fatigue and insomnia.
Although known mostly for its anti-inflammatory effects, curcumin clearly has value for positively impacting stress/anxiety and sleep due at least in part to its ability to increase serotonin levels.
Gene Bruno, MS, MHS, RH (AHG) possesses 42 years of dietary supplement industry experience. With a master’s degree in nutrition and a second master’s degree in herbal medicine, he has a proven track record of formulating innovative, evidence-based dietary supplements. Bruno currently serves as both the vice president of scientific and regulatory affairs at NutraScience Labs (Farmingdale, NY) and professor of nutraceutical science at Huntington University of Health Sciences (Knoxville, TN).
- PR Newswire press release. “Curcumin Market Is Anticipated to Grow to $94.3 Million By 2022: Grand View Research, Inc.” Published June 22, 2015.
- Global Market Insights report. “Curcumin Market Size to Exceed $145 Mn by 2027.” Published July 14, 2021.
- “Curcuma longa (turmeric). Monograph.” Alternative Medicine Review, supplement 6 (September 2001): S62-S66
- Togni S, Appendino G. “Curcumin and Joint Health: From Traditional Knowledge to Clinical Validation.” Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases edited by Watson RR, Preedy VR Academic Press 2013: 67-81
- Kulkarni SK et al. “Antidepressant activity of curcumin: Involvement of serotonin and dopamine system.” Psychopharmacology (Berl), vol. 201, no. 3 (December 2008): 435-342
- Xu Y et al. “Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats.” Brain Research. Published online June 21, 2007.
- Jagota A et al. “The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.” Cellular and Molecular Neurobiology, vol. 27, no. 8 (December 2007): 997-1006
- Aubry AV et al. “A diet enriched with curcumin promotes resilience to chronic social defeat stress.” Neuropsychopharmacology, vol. 44, no. 4 (March 2019):733-742
- Esmaily H et al. “An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.” Chinese Journal of Integrative Medicine. Published online March 17, 2015.
- Asadi S et al. “Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial.” Phytotherapy Research, vol. 34, no. 4 (April 2020): 896-903
- Lopresti AL et al. “Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study.” Journal of Affective Disorders, vol. 207 (January 1, 2017): 188-196
- Esmaily H et al. “An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.” Chinese Journal of Integrative Medicine, vol. 21, no. 5 (May 2015): 332-338
- Panahi Y et al. “Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorder.” Phytotherapy Research, vol. 29, no. 1 (January 2015): 17-21
- Nouri-Vaskeh M et al. “Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial.” Complementary Therapies in Medicine. Published online February 19, 2020.
- Kalluru H et al. “Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: A case series.” Complementary Therapies in Clinical Practice. Published online October 13, 2020.